Serotonin Toxicity: Implications for Clinical Practice


Serotonin toxicity
serotonin syndrome
selective serotonin reuptake inhibitors
tricyclic antidepressants
monoamine oxidase inhibitors
adverse drug reactions
drug overdoses
diagnostic criteria
clinical practice

How to Cite

Rotheram A, Harris W, Curtain C, Nihill D. Serotonin Toxicity: Implications for Clinical Practice. Australasian Journal of Paramedicine [Internet]. 2016Jul.31 [cited 2021Sep.22];13(3). Available from:


Serotonin toxicity, or serotonin syndrome, is a potentially life threatening adverse reaction to the use of one or more serotonergic drugs. Patients presenting with low level obscure symptoms may have pathophysiology rooted in adverse dopamine and serotonergic poly-pharmacy reactions involving illegal, over-the-counter and/or prescription drugs. In this clinical information paper an overview of serotonin toxicity, diagnostic criteria, and management strategies will be offered. Cultivating a high index of suspicion for serotonin toxicity across a broad patient demographic is recommended


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