Serotonin Toxicity: Implications for Clinical Practice

Auston Rotheram, Wayne Harris, Colin Curtain, David Nihill

Abstract


Serotonin toxicity, or serotonin syndrome, is a potentially life threatening adverse reaction to the use of one or more serotonergic drugs. Patients presenting with low level obscure symptoms may have pathophysiology rooted in adverse dopamine and serotonergic poly-pharmacy reactions involving illegal, over-the-counter and/or prescription drugs. In this clinical information paper an overview of serotonin toxicity, diagnostic criteria, and management strategies will be offered. Cultivating a high index of suspicion for serotonin toxicity across a broad patient demographic is recommended

Keywords


Serotonin toxicity; serotonin syndrome; selective serotonin reuptake inhibitors; tricyclic antidepressants; monoamine oxidase inhibitors; MDMA; ecstasy; adverse drug reactions; drug overdoses; diagnostic criteria; clinical practice; paramedicine

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References


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DOI: http://dx.doi.org/10.33151/ajp.13.3.497

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